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A Case of Churg-Strauss Syndrome with Multiple Tracheobronchial Mucosal Lesions / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 405-409, 2008.
Article in Korean | WPRIM | ID: wpr-168139
ABSTRACT
Churg-Strauss syndrome is a rare form of systemic necrotizing vasculitis that occurs exclusively in patients with asthma, and is associated with blood and tissue eosinophilia. The classic pathology findings in the lung include a combination of eosinophilic pneumonia, granulomatous inflammation and necrotizing vasculitis. However, there are few reports of tracheobronchial mucosal lesions in Churg-Strauss syndrome. We report a case of Churg-Strauss syndrome with multiple tracheobronchial mucosal lesions in a 33-year-old man with a history of bronchial asthma and allergic rhinitis. He had been diagnosed with community acquired pneumonia at another hospital and was treated with antibiotics. However, the chest radiographic findings were aggravated and showed multifocal consolidations in the whole lung fields. He was transferred to the Asan Medical Center. Fiberoptic bronchoscopy revealed multiple nodular mucosal lesions of the trachea and bronchi. The histopathology of the mucosal lesions revealed necrotizing bronchial inflammation with eosinophilic infiltration. Video Assisted Thoracic Surgery was performed. The wedge resected lung tissue revealed chronic eosinophilic pneumonia that was consistent with Churg-Strauss syndrome. Methylprednisolone (1 mg/kg q 8 hr) was prescribed and his symptoms resolved gradually. The chest radiographic findings improved significantly, and a follow-up fiberoptic bronchoscopy performed eight days later showed that the tracheobronchial mucosal lesions had resolved. The patient was prescribed oral prednisolone for 20 months after discharge. Currently, the patient is not taking steroids and is being followed up.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumonia / Pulmonary Eosinophilia / Asthma / Steroids / Thorax / Trachea / Vasculitis / Bronchi / Bronchoscopy / Methylprednisolone Type of study: Observational study / Prognostic study Limits: Adult / Humans Language: Korean Journal: Tuberculosis and Respiratory Diseases Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumonia / Pulmonary Eosinophilia / Asthma / Steroids / Thorax / Trachea / Vasculitis / Bronchi / Bronchoscopy / Methylprednisolone Type of study: Observational study / Prognostic study Limits: Adult / Humans Language: Korean Journal: Tuberculosis and Respiratory Diseases Year: 2008 Type: Article