A Case of Kasabach-Merritt Syndrome Diagnosed by Fetal Ultrasonography
Journal of the Korean Society of Neonatology
;
: 114-118, 2007.
Article
in Korean
| WPRIM
| ID: wpr-16816
ABSTRACT
In 1940, Kasabach and Merritt first described the association of a large vascular tumor and thrombocytopenia and termed this Kasabach-Merritt syndrome. This is characterized by a rapidly enlarging hemangioma with thrombocytopenia and coagulopathy. We describe an infant with a large complex vascular lesion of the face that was diagnosed in utero and successfully treated interferon and pentoxyfylline. In a fetus at 36+0 weeks gestation, ultrasound demonstrated abnormality of the face and neck. she was delivered at 38+5 weeks gestation with a large facial hemangioma. She had severe thrombocytopenia in the first 24hr of life (platelets 22,000/microliter) and she was commenced on oral steroids(prednisolone 2 mg/kg/day). The hemangioma continued to grow and the baby required frequent platelet transfusions. When the infant was 17 days old, treatment with pentoxyfylline and subcutaneous alpha interferon(initially 60,000 units/m2/day) was started. From 1 month of age, the hemangioma gradually reduced in volume and the platelet count stared to rise. Recent, the hemangioma progressively diminished in size without any serious complication.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Thrombocytopenia
/
Ultrasonography, Prenatal
/
Ultrasonography
/
Interferons
/
Interferon-alpha
/
Platelet Transfusion
/
Fetus
/
Kasabach-Merritt Syndrome
/
Hemangioma
Type of study:
Diagnostic study
Limits:
Humans
/
Infant
/
Pregnancy
Language:
Korean
Journal:
Journal of the Korean Society of Neonatology
Year:
2007
Type:
Article
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