Evidence-Based Korean Pharmacological Treatment Guideline for Depression, Revised Edition (II) : Antidepressant Efficacy Compared with Placebo, Difference in Efficacy of Antidepressants, and Appropriate Time of Efficacy Judgment in Antidepressant Therapy / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 372-385, 2013.
Article
in Korean
| WPRIM
| ID: wpr-168401
ABSTRACT
OBJECTIVES:
The purpose of this study was to suggest recommendations of antidepressant efficacy compared with placebo, difference in efficacy of antidepressants, and appropriate time of efficacy judgment in antidepressant therapy.METHODS:
Using recommendations from 12 international and domestic clinical practice guidelines for depression, drawing of recommendation drafts, and peer review, the executive committee developed the guideline.RESULTS:
Tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOI), selective serotonin reuptake inhibitors (SSRI), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and specific serotonergic antidepressants (NaSSAs), norepinephrine and dopamine reuptake inhibitors (NDRIs), and serotonin antagonist and reuptake inhibitors (SARIs) were strongly recommended as having antidepressant efficacy compared with placebo. Difference in efficacy of antidepressants was as follows. TCAs, MAOI, SSRI, SNRIs, and NaSSAs were strongly recommended, however, NDRIs, SARIs were weakly recommended. If there was no or minimal improvement with treatment, appropriate time of efficacy judgment in antidepressant therapy was estimated to be after two to four weeks.CONCLUSION:
We hope that the results of this study will be helpful in encouraging the optimal treatment by understanding antidepressant efficacy compared with placebo, difference in efficacy of antidepressants, and appropriate time of efficacy judgment in antidepressant therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peer Review
/
Serotonin
/
Norepinephrine
/
Selective Serotonin Reuptake Inhibitors
/
Dopamine Uptake Inhibitors
/
Depression
/
Depressive Disorder, Major
/
Judgment
/
Monoamine Oxidase Inhibitors
/
Antidepressive Agents
Type of study:
Controlled clinical trial
/
Practice guideline
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2013
Type:
Article
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