Hand-Foot Syndrome with Nail Changes Induced by Fluorouracil / 대한피부과학회지

ABSTRACT

Many chemotherapeutic agents induce both local and systemic cutaneous toxicity. Among them, Fluorouracil (5-FU) induces various cutaneous reaction, including hand-foot syndrome, hypersensitivity, hyperpigmentation and nail changes. We describe a male patient with rectal cancer, who developed combined features of hand-foot syndrome and nail changes during chemotherapy with 5-FU.