A Case Report of t(8;22) with Additional Chromosomal Defects in Bone Marrow Involvement of B Cell Type Diffuse Large Cell Lymphoma / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 525-528, 1998.
Article
in Korean
| WPRIM
| ID: wpr-16877
ABSTRACT
The t(8;14)(q24;q32) translocation or its variants, t(2;8)(p12;q24) and t(8;22)(q24;q32) are classically seen in Burkitt's lymphoma, but are also found in diffuse large cell lymphoma (DLCL). Burkitt's lymphoma is very rare in Korea and t(8;14) or its variants have not been reported. We report a case of DLCL (B-cell type) with t(8;22) and additional chromosomal abnormalities. The patient, 45-year-old male, complained intermittent abdominal pain. The histologic examination of sigmoid colon revealed DLCL. Lymphoma cells were counted about 58.8% of all nucleated cells in bone marrow aspiration and showed surface membrane immunoglobulin positivity. Chromosome study of bone marrow aspiration was done using high resolution banding technique. The karyotype was 47,XY,+1,del(6)(q21),t(8;22)(q24;q11),del(13)(q31),der(14)t(1;14)(q23;q32)?, del(17)(p11) in all of the nineteen metaphases which were analyzed. Although he was treated by chemotherapy and radiotherapy, lymphoma cells were increased in peripheral blood and he expired.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiotherapy
/
Colon, Sigmoid
/
Bone Marrow
/
Immunoglobulins
/
Abdominal Pain
/
Chromosome Aberrations
/
Lymphoma, Large B-Cell, Diffuse
/
Burkitt Lymphoma
/
Drug Therapy
/
Karyotype
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Clinical Pathology
Year:
1998
Type:
Article
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