The Effect of Carbon Monoxide Intoxication on The Metabolites of Monoamine Neurotransmitters in Human Cerbrospinal Fluid
Journal of the Korean Neurological Association
;
: 249-255, 1990.
Article
in Korean
| WPRIM
| ID: wpr-168835
ABSTRACT
This study was done in order to show the effects of carbon rnonoxide (CO) induced hypoxia on the steps of metabolism of rnonoamine neurotransmitters. There were 9 patients exposed to CO and 5 patients of control group. We evaluated their cerebrospinal fluid within 24 hours after CO exposure. And we measured the amounts of 5-hydroxy-indole acetic acid (5-HIAA) and homovanillic acid (HVA) with high performance liquid chromatography (HPLC). In the CO exposure group, the levels of 5-HIAA and HVA were reduced compared with the control group. It was thought that the changes in the levels of 5-HIAA and HVA were due to the transient decrease in monoamine oxidase activity in acute hypoxia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carbon
/
Carbon Monoxide
/
Cerebrospinal Fluid
/
Chromatography, Liquid
/
Neurotransmitter Agents
/
Acetic Acid
/
Homovanillic Acid
/
Hydroxyindoleacetic Acid
/
Hypoxia
/
Metabolism
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
1990
Type:
Article
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