Cytogenetic Findings in Patients with Acquired Aplastic Anemia / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 240-245, 2001.
Article
in Korean
| WPRIM
| ID: wpr-168887
ABSTRACT
BACKGROUND:
Cytogenetic abnormalities have been described in a few patients with otherwise typical aplastic anemia, and the possible clonal nature of this disease is a controvertial issue.METHODS:
We analyzed bone marrow samples from 57 acquired aplastic anemia patients. Cytogenetic studies were performed using the standard G-banding with trypsin-Giemsa staining. For 18 patients who showed neither analyzable mitotic cells nor more than 5 metaphases in the conventional chromosome analysis, the interphase FISH analysis was performed using CEP 8 and 7 for the detection of trisomy 8 and monosomy 7, which are the most commonly reported chromosomal abnormalities in patients with aplastic anemia.RESULTS:
Of the 57 aplastic anemia patients, 10 patients (17.5%) had chromosomal abnormalities at the time of diagnosis. The chromosomal abnormalities were as follows 3 cases of trisomy 8, and one case each of trisomy 8 and 9, t(8;21), inv(16), t(4;14), t(X;19), del(10), and monosomy 10. One patient with trisomy 8 showed persistent chromosomal abnormality after immunosuppressive therapy and evolved to myelodysplastic syndrome after 53 months.CONCLUSIONS:
The frequency of the chromosomal abnormalities in acquired aplastic anemia at diagnosis seems to be higher than those of previous studies in Caucasian population. A proportion of acquired aplastic anemia may be associated with lineage-commitment progenitor cell defect and has potential for a myeloid specific leukemic evolution.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Trisomy
/
Bone Marrow
/
Myelodysplastic Syndromes
/
Chromosome Aberrations
/
Cytogenetics
/
Diagnosis
/
Anemia, Aplastic
/
Interphase
/
Metaphase
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Clinical Pathology
Year:
2001
Type:
Article
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