A Case of Hemolytic Uremic Syndrome Following Mitomycin C Treated with Long Intensive Plasmapheresis / 대한신장학회지
Korean Journal of Nephrology
;
: 662-666, 2010.
Article
in Korean
| WPRIM
| ID: wpr-168909
ABSTRACT
HUS (Hemolytic Uremic Syndrome) is characterized by acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia. In classical HUS, hemorrhagic diarrhea precedes. It is frequently associated with E. Coli O157H7. Less frequently, HUS may also develop after various treatments such as mitomycin C, cyclosporine, quinine, and ticlopidine. Plasmapheresis is effective in most of classical HUS, which induces a complete remission in most patients with classical HUS. However, this treatment is ineffective in HUS associated with mitomycin C. Although Plasmapheresis is effective on hematologic abnormality in this atypical HUS, chronic renal insufficiency frequently persists as a sequella in HUS associated with mitomycin C. We here report on one patient who developed HUS following mitomycin C therapy due to cervix cancer. The patient was treated with intensive and prolonged plasmapheresis. There was a complete hematologic improvement and steady improvement in renal function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quinine
/
Thrombocytopenia
/
Ticlopidine
/
Uterine Cervical Neoplasms
/
Plasmapheresis
/
Mitomycin
/
Cyclosporine
/
Diarrhea
/
Renal Insufficiency, Chronic
/
Acute Kidney Injury
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2010
Type:
Article
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