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Expression of c-erbB-2 and Cyclooxygenase-2 in Pancreatic Ductal Adenocarcinoma
Korean Journal of Pathology ; : 171-175, 2007.
Article in English | WPRIM | ID: wpr-169051
ABSTRACT

Background:

Carcinoma of the pancreas is a fatal malignant disease with limited therapeutic options. Cyclooxygenase-2 (COX-2) and c-erbB-2 are known to be involved in the carcinogenesis, differentiation and invasiveness of various neoplasms. We studied the immunohistochemical expressions of c-erbB-2 and COX-2 and the correlation between these expressions and the clinicopathologic parameters and the relation between the expressions.

Methods:

Immunohistochemical staining for c-erbB-2 and COX-2 were performed on the paraffin embedded sections of 36 cases of surgically resected ductal adenocarcinoma of the pancreas and 10 cases of non-neoplastic pancreas tissue.

Results:

The non-neoplastic control group showed a c-erbB-2 expression in the acini (8/10) and ducts (2/10), and a COX-2 expression in the acini (6/10) and ducts (3/10). The overexpression of c-erbB-2 was observed in 58% (21/36) of the carcinoma specimens. No significant correlation was found between c-erbB-2 and age, gender, tumor size, gross type, histologic grade, vascular invasion, perineural invasion, lymph node metastasis, and the TNM stage. The overexpression of COX-2 was observed in 41.7% (15/36) of the carcinoma specimens. The COX-2 expression was significantly high in the lymph node metastasis group (p<0.05), but it was not correlated with the other clinicopathologic parameters. Also there was no significant correlation between the c-erbB-2 and COX-2 expressions.

Conclusions:

In pancreatic ductal adenocarcinomas, c-erbB-2 and COX-2 were frequently overexpressed, and COX-2 overexpression was correlated with lymph node metastasis.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreas / Pancreatic Ducts / Paraffin / Immunohistochemistry / Adenocarcinoma / Receptor, ErbB-2 / Cyclooxygenase 2 / Carcinogenesis / Lymph Nodes / Neoplasm Metastasis Language: English Journal: Korean Journal of Pathology Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreas / Pancreatic Ducts / Paraffin / Immunohistochemistry / Adenocarcinoma / Receptor, ErbB-2 / Cyclooxygenase 2 / Carcinogenesis / Lymph Nodes / Neoplasm Metastasis Language: English Journal: Korean Journal of Pathology Year: 2007 Type: Article