C-reactive protein/albumin ratio as prognostic score in oral squamous cell carcinoma
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 243-250, 2016.
Article
in English
| WPRIM
| ID: wpr-169374
ABSTRACT
OBJECTIVES:
Many studies have examined histopathological factors and various prognostic scores related to inflammation to predict outcomes. Here, we examined the prognostic value of the C-reactive protein/albumin (CRP/alb) ratio in oral squamous cell carcinoma (OSCC). MATERIALS ANDMETHODS:
This retrospective study included 40 patients with OSCC. Using univariate and multivariate analyses, we focused on the correlation of the CRP/alb ratio with clinicopathological characteristics and with overall survival. We then compared five inflammation-based prognostic scores, CRP/alb ratio, modified Glasgow Prognostic Score (mGPS), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and prognostic nutritional index (PNI), based on receiver operating characteristic (ROC) curves.RESULTS:
The optimal cut-off value for the CRP/alb ratio was 0.085. The group with a high CRP/alb ratio had a high TNM clinical stage (P=0.002) and larger primary tumors (P=0.029), with statistically significant differences in lymph node metastasis and distant metastasis. In addition, when the CRP/alb ratio was high, multivariate analysis showed a lower survival rate (P=0.002; hazard ratio=6.078), and the ROC curve showed more outstanding discriminatory ability regarding overall survival compared to other inflammation-based prognostic scores.CONCLUSION:
The CRP/alb ratio can be an independent prognostic factor when predicting prognosis in OSCC and has good prognostic ability.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
C-Reactive Protein
/
Carcinoma, Squamous Cell
/
Nutrition Assessment
/
Multivariate Analysis
/
Survival Rate
/
Retrospective Studies
/
ROC Curve
/
Epithelial Cells
/
Inflammation
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2016
Type:
Article
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