Understanding the Molecular Biology in the Pathogenesis of Depression / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 147-154, 2012.
Article
in Korean
| WPRIM
| ID: wpr-169422
ABSTRACT
Depression is a common psychiatric illness with a high lifetime prevalence in the general population. Serious problem, such as suicide is commonly occurring in the patients with depression. Till now, the monoamine hypothesis has been the most popular theory of pathogenesis for depression. However, the more specific pathophysiology of depression and cellular molecular mechanism underlying action of commercial antidepressant has not been clearly defined. Several recent studies demonstrated that neural plasticity, epigenetic and mammalian target of rapamycin signaling are promising answers to the pathophysiology of depression. In this article, current understanding of biology and molecular mechanisms of depression and new research on the pathophysiology of depression will be discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plastics
/
Suicide
/
Biology
/
Prevalence
/
Sirolimus
/
Depression
/
Epigenomics
/
Molecular Biology
Type of study:
Etiology study
/
Prevalence study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2012
Type:
Article
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