A case of valproic acid-induced hyperammonemic encephalopathy with normal liver function / 대한내과학회지
Korean Journal of Medicine
;
: 680-684, 2008.
Article
in Korean
| WPRIM
| ID: wpr-169544
ABSTRACT
Valproic acid is an effective anticonvulsant used in neurology and psychiatry. Valproic acid-induced hyperammonemic encephalopathy is an unusual complication characterized by a decreasing level of consciousness, the development of progressive confusional states and, sometimes, a coexisting increase in the frequency of seizures after the onset of valproic acid treatment. It can lead to death, but can be reversed if a swift diagnosis is made. We report the case of a 58-year-old woman with an intracerebral hemorrhage and normal liver function who presented with valproic acid-induced hyperammonemic encephalopathy. After valproic acid treatment, she developed encephalopathy and became comatose, with seizures and a markedly elevated serum ammonia level. Her neurologic manifestations and hyperammonemia improved after discontinuing the valproic acid.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seizures
/
Cerebral Hemorrhage
/
Valproic Acid
/
Coma
/
Consciousness
/
Hyperammonemia
/
Ammonia
/
Liver
/
Neurologic Manifestations
/
Neurology
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2008
Type:
Article
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