Carbon monoxide poisoning as an epigenetic factor for Leber's hereditary optic neuropathy
Korean Journal of Ophthalmology
;
: 122-123, 1996.
Article
in English
| WPRIM
| ID: wpr-169585
ABSTRACT
A 45-year-old Korean woman visited our hospital complaining of poor vision after carbon monoxide (CO) poisoning. We have confirmed the presence of a point mutation at position 11778 in the ND4 gene of mitochondrial DNA. This case suggests that CO poisoning may precipitate the clinical expression of Leber's hereditary optic neuropathy (LHON). To our knowledge, this would be the first case report of clinical expression of LHON precipitated by CO poisoning.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA Damage
/
DNA, Mitochondrial
/
Carbon Monoxide
/
Carbon Monoxide Poisoning
/
Visual Acuity
/
Optic Atrophies, Hereditary
/
Point Mutation
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
1996
Type:
Article
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