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Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat
Journal of Korean Medical Science ; : 31-36, 1991.
Article in English | WPRIM | ID: wpr-169609
ABSTRACT
The modifying potential of capsaicin (CAP) on lesion development was examined in a rat multiorgan carcinogenesis model. Groups 1 and 2 were treated sequentially with diethylnitrosamine (DEN) (100 mg/kg, ip, single dose at commencement), N-methylnitrosourea (MNU) (20 mg/kg, ip, 4 doses at days 2, 5, 8, and 11), and N,N-dibutylnitrosamine (DBN) (0.05% in drinking water during weeks 3 and 4). Group 3 received vehicles without carcinogens during the initiation period. Group 4 served as the untreated control. After this initiating procedure, Groups 2 and 3 were administered a diet containing 0.01% CAP. All surviving animals were killed 20 weeks after the beginning of the experiment and the target organs examined histopathologically. The induction of GST-P+ hepatic foci in rats treated with carcinogens was significantly inhibited by treatment with CAP. CAP treatment significantly decreased the incidence of adenoma of the lung but increased the incidence of papillary or nodular (PN) hyperplasia of the urinary bladder. The tumor incidence of other organs, such as the kidney and thyroid, was not significantly different from the corresponding controls. These results demonstrated that concurrent treatment with CAP not only can inhibit carcinogenesis but can also enhance it depending on the organ. Thus, this wide-spectrum initiation model could be used to confirm organ-specific modification potential and, in addition, demonstrate different modifying effects of CAP on liver, lung, and bladder carcinogenesis.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rats, Inbred F344 / Urinary Bladder Neoplasms / Capsaicin / Cocarcinogenesis / Diethylnitrosamine / Liver Neoplasms, Experimental / Lung Neoplasms / Methylnitrosourea / Neoplasms, Experimental / Nitrosamines Limits: Animals Language: English Journal: Journal of Korean Medical Science Year: 1991 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rats, Inbred F344 / Urinary Bladder Neoplasms / Capsaicin / Cocarcinogenesis / Diethylnitrosamine / Liver Neoplasms, Experimental / Lung Neoplasms / Methylnitrosourea / Neoplasms, Experimental / Nitrosamines Limits: Animals Language: English Journal: Journal of Korean Medical Science Year: 1991 Type: Article