Topical Photodynamic Therapy for Treatment of Actinic Keratosis Using Light-Emitting Diode (LED) Device / 대한피부과학회지
Korean Journal of Dermatology
;
: 469-474, 2005.
Article
in Korean
| WPRIM
| ID: wpr-169834
ABSTRACT
BACKGROUND:
Photodynamic therapy is a treatment modality which involves the sequential administration of a photosensitizer and light. Topical photodynamic therapy is being increasingly used for superficial non-melanoma skin cancers and their precursors.OBJECTIVE:
The purpose of this study was to evaluate the effectiveness and side effects of treating actinic keratosis with photodynamic therapy using a light-emitting diode device and 20% 5-aminolevulinic acid.METHODS:
Photodynamic therapy, with a 630+/-50nm light-emitting diode device and 5-aminolevulinic acid, was used to treat 12 lesions of actinic keratosis on 8 patients. The light intensity used was 50mW/cm2 , and the light dose was 100-120J/cm2 . Four weeks after 1 or 2 treatment sessions, the outcome was evaluated by histopathological findings.RESULTS:
Complete clearance was achieved in 8 of 12 lesions after a single treatment, and in 3 of 12 lesions after 2 treatment sessions. Only 1 case showed partial response after 2 treatment sessions. Only 2 patients suffered from a stinging sensation when exposed to the light therapy.CONCLUSION:
Topical photodynamic therapy using a light-emitting diode is safe and effective in the treatment of actinic keratosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phototherapy
/
Photochemotherapy
/
Sensation
/
Skin Neoplasms
/
Bites and Stings
/
Actins
/
Keratosis, Actinic
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2005
Type:
Article
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