Expression of Transforming Growth Factor-beta Receptors in Food Protein-Induced Enterocolitis Syndrome in Infancy / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 36-43, 2002.
Article
in Korean
| WPRIM
| ID: wpr-169873
ABSTRACT
PURPOSE:
Food protein-induced enterocolitis syndrome (FPIES) is a symptom complex of vomiting and diarrhea caused by non-IgE mediated allergy to cow's milk and/or soy in young infants. Transforming growth factor (TGF)-beta has been reported to protect the epithelial barrier of the gut from foreign antigens. We studied the expression of type 1 and 2 TGF-beta receptors in the mucosa of small intestine to investigate their roles in the pathogenesis of FPIES.METHODS:
Twenty-eight patients, aged 7 to 120 days (mean 49 days) who were diagnosed with FPIES by clinical criteria and challenge tests were included. Immunohistochemical stainings for type 1 and 2 TGF-beta receptors were performed on endoscopic duodenal biopsy specimens.RESULTS:
Type 1 and 2 TGF-beta receptors were expressed in the villous and crypt epithelial cells but nearly absent in the lamina propria in both patients and controls. Type 1 TGF-beta receptor expression was significantly lower in the patients who had villous atrophy than in the patients who had not and in controls. The expression of type 1 TGF-beta receptor was negatively correlated with the severity of villous atrophy. Type 2 TGF-beta receptor expression showed no significant difference between the patients and controls.CONCLUSION:
Our results suggests that the decreased activity of type 1 TGF-beta receptor is implicated in the pathogenesis of FPIES in young infants.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Atrophy
/
Vomiting
/
Biopsy
/
Transforming Growth Factors
/
Receptors, Transforming Growth Factor beta
/
Milk
/
Diarrhea
/
Enterocolitis
/
Epithelial Cells
/
Hypersensitivity
Limits:
Humans
/
Infant
Language:
Korean
Journal:
Pediatric Allergy and Respiratory Disease
Year:
2002
Type:
Article
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