Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy
Journal of Korean Medical Science
;
: 718-721, 2007.
Article
in English
| WPRIM
| ID: wpr-169943
ABSTRACT
Adenosine deaminase (ADA), an enzyme essential for the differentiation of lymphoid cells, has been used for monitoring diseases with altered immunity. The purpose of this study was to investigate the changes in serum ADA activity throughout normal pregnancy. We measured the catalytic values of serum ADA from 202 normal pregnant women using a commercial kit. Subjects were divided into four groups according to the gestational age in weeks (Gwks) (Group I 5-9 Gwks [n=58]; Group II 15-20 Gwks [n= 63]; Group III 24-30 Gwks [n=34]; Group IV 30-39 Gwks [n=47]). The serum ADA levels for the Groups I, II, III, and IV were as follows 20.1+/-6.9 IU/L, 20.0+/-7.6 IU/L, 37.9+/-19.9 IU/L, and 24.5+/-8.6 IU/L, respectively. The serum ADA activity of group III was significantly higher than the other groups (p<0.05). However, there was no significant correlation between the Gwks and the serum ADA activity. Furthermore, other parameters, such as maternal age (p=0.29), gestational age at delivery (p=0.07), delivery mode (p=0.39), and birth weight (p=0.59) had no correlation with ADA activity. Reference values of serum ADA in normal pregnancy may provide important database for making clinical decisions in pregnancies complicated by conditions where cellular immunity has been altered.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Substrate Specificity
/
Birth Weight
/
Logistic Models
/
Adenosine
/
Adenosine Deaminase
/
Analysis of Variance
/
Gestational Age
/
Maternal Age
/
Inosine
Type of study:
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2007
Type:
Article
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