Your browser doesn't support javascript.
loading
Efficacy of the Mineral Oil and Hyaluronic Acid Mixture Eye Drops in Murine Dry Eye
Korean Journal of Ophthalmology ; : 131-137, 2015.
Article in English | WPRIM | ID: wpr-170373
ABSTRACT

PURPOSE:

To investigate the therapeutic effects of mineral oil (MO) and hyaluronic acid (HA) mixture eye drops on the tear film and ocular surface in a mouse model of experimental dry eye (EDE).

METHODS:

Eye drops consisting of 0.1% HA alone or mixed with 0.1%, 0.5%, or 5.0% MO were applied to desiccating stress-induced murine dry eyes. Tear volume, corneal irregularity score, tear film break-up time (TBUT), and corneal fluorescein staining scores were measured at 5 and 10 days after treatment. Ten days after treatment, goblet cells in the conjunctiva were counted after Periodic acid-Schiff staining.

RESULTS:

There was no significant difference in the tear volume between desiccating stress-induced groups. The corneal irregularity score was lower in the 0.5% MO group compared with the EDE and HA groups. The 0.5% and 5.0% MO groups showed a significant improvement in TBUT compared with the EDE group. Mice treated with 0.1% and 0.5% MO mixture eye drops showed a significant improvement in fluorescein staining scores compared with the EDE group and the HA group. The conjunctival goblet cell count was higher in the 0.5% MO group compared with the EDE group and HA group.

CONCLUSIONS:

The MO and HA mixture eye drops had a beneficial effect on the tear films and ocular surface of murine dry eye. The application of 0.5% MO and 0.1% HA mixture eye drops could improve corneal irregularity, the corneal fluorescein staining score, and conjunctival goblet cell count compared with 0.1% HA eye drops in the treatment of EDE.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Ophthalmic Solutions / Tears / Mineral Oil / Dry Eye Syndromes / Conjunctiva / Cornea / Goblet Cells / Disease Models, Animal / Drug Combinations / Emollients Type of study: Prognostic study Limits: Animals Language: English Journal: Korean Journal of Ophthalmology Year: 2015 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Ophthalmic Solutions / Tears / Mineral Oil / Dry Eye Syndromes / Conjunctiva / Cornea / Goblet Cells / Disease Models, Animal / Drug Combinations / Emollients Type of study: Prognostic study Limits: Animals Language: English Journal: Korean Journal of Ophthalmology Year: 2015 Type: Article