Your browser doesn't support javascript.
loading
Irinotecan, Continuous 5-Fluorouracil, and Low dose of Leucovorin (modified FOLFIRI) as First Line of Therapy in Recurrent or Metastatic Colorectal Cancer
The Korean Journal of Internal Medicine ; : 205-209, 2005.
Article in English | WPRIM | ID: wpr-170415
ABSTRACT

BACKGROUND:

Irinotecan, in combination with 5-fluorouracil (5-FU) and a high dose of leucovorin (LV), known as FOLFIRI regimen, has shown activity in recurrent or metastatic colorectal cancer. Therefore, we evaluated the efficacy and safety of irinotecan, 5-FU and a low dose of LV (modified FOLFIRI) as a first line of therapy for patients with relapsed or metastatic colorectal cancer.

METHODS:

Between January 2002 and October 2004, 44 patients with histologically confirmed recurrent or metastatic colorectal cancer were enrolled. The chemotherapy regimen schedule consisted of 180 mg/m2 of irinotecan being administered intravenously (i.v) on Day 1, 400 mg/m2 of 5-FU via i.v bolus with 600 mg/m2 of continuous infusion for 22 hrs on both Day 1 and 2, and 20 mg/m2 of leucovorin on both Day 1 and 2, repeated every two weeks.

RESULTS:

The overall response rate was 47.8%. Of the 40 evaluated patients, one had CR (2.3%) and 20 had PR (46.5%). Toxicities were mild and easily manageable. Three patients experienced 23 episodes of Grade 3/4 leukopenia., Only one patient developed Grade 3/4 diarrhea. None experienced Grade 3/4 thrombocytopenia.

CONCLUSION:

Modified FOLFIRI with a low dose of LV is an effective and tolerable regimen for patients with recurrent or metastatic colorectal cancer.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Camptothecin / Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Leucovorin / Disease Progression / Fluorouracil / Neoplasm Metastasis / Neoplasm Recurrence, Local Limits: Adult / Aged / Female / Humans / Male Language: English Journal: The Korean Journal of Internal Medicine Year: 2005 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Camptothecin / Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Leucovorin / Disease Progression / Fluorouracil / Neoplasm Metastasis / Neoplasm Recurrence, Local Limits: Adult / Aged / Female / Humans / Male Language: English Journal: The Korean Journal of Internal Medicine Year: 2005 Type: Article