Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action
Experimental & Molecular Medicine
;
: 673-678, 2007.
Article
in English
| WPRIM
| ID: wpr-170419
ABSTRACT
Lipoprotein plays a role in the host defense against bacterial infection, and its serum level has been demonstrated to be an important prognosis factor of survival. We have previously demonstrated that LDL directly inactivates the hemolytic activity of Vibrio vulnificus cytolysin (VVC) in vitro. The object of this study was therefore to examine whether the LDL-mediated inactivation of VVC leads to protection against lethal infection of V. vulnificus in vivo, using wild and VVC-deficient V. vulnificus strains. Unexpectedly, we found that LDL protects mouse lethality induced by VVC-deficient as well as wild V. vulnificus strain. We also demonstrated that LDL blocks V. vulnificus LPS-induced lethality in mice. These results suggest that LDL preferentially act on endotoxin rather than exotoxin in the protection against V. vulnificus-induced mice lethality.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vibrio Infections
/
Virulence
/
Lipopolysaccharides
/
Vibrio vulnificus
/
Disease Models, Animal
/
Perforin
/
Lipoproteins, LDL
/
Mice, Inbred ICR
Type of study:
Prognostic study
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2007
Type:
Article
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