Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants
Obstetrics & Gynecology Science
;
: 22-28, 2013.
Article
in English
| WPRIM
| ID: wpr-170623
ABSTRACT
OBJECTIVE:
The objective of this study was to determine the differences in urinary nephrin among controls, gravidas with preeclampsia (PE), and small-for-gestational age (SGA) infants. We also determined whether or not maternal urinary concentrations of nephrin are associated with the subsequent development of PE and SGA infants.METHODS:
We analyzed maternal urinary levels of nephrin in women who were normal controls (n=50), women who were delivered SGA infants (n=40), and gravidas with PE (n=33) in the first, second and third trimesters. Urinary nephrin concentrations were measured with nephrin enzyme-linked immunosorbent assay kits.RESULTS:
The levels of urinary nephrin were higher in gravida developing preeclampsia or SGA than in controls after adjusting serum creatinine (P<0.05 for both). Maternal urine concentrations of nephrin were higher in pregnancies complicated by SGA and PE in the third trimester (P<0.05), and also higher in pregnancies complicated by SGA in the first trimester (P<0.05). The sensitivity and specificity of nephrin in predicting SGA from normal pregnancies were 67% and 89% in the first trimester, 60% and 79% in the second trimester, and 80% and 84% in the third trimester, respectively. The sensitivity and specificity of nephrin in predicting PE from normal pregnancies were 67% and 83% in the first trimester and 73% and 79% in the third trimester, respectively.CONCLUSION:
We suggest that urinary nephrin can be used as an early marker in pregnancies at risk for developing PE and SGA infants.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pre-Eclampsia
/
Pregnancy Trimester, Second
/
Pregnancy Trimester, Third
/
Pregnancy Trimester, First
/
Enzyme-Linked Immunosorbent Assay
/
Sensitivity and Specificity
/
Creatinine
/
Membrane Proteins
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Infant
/
Pregnancy
Language:
English
Journal:
Obstetrics & Gynecology Science
Year:
2013
Type:
Article
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