Clinical Study on Chronic Granulomatous Disease(CGD) -Occurrence in Siblings-
Journal of the Korean Pediatric Society
;
: 794-803, 1994.
Article
in Korean
| WPRIM
| ID: wpr-170746
ABSTRACT
To analyse the age of onset, etiologic microorganisms, clinical manifestations, managements and genetic variation of chromic granulomatous disease, the authors reviewed four patients who were diagnosed as CGD at Department of Pediatrics, Seoul National Univesity Children's Hospital. They were siblings in relationship-two of them were brothers, the others were brother-sister. @ES The results were as follows; 1) Initial manifestations developed within 1 year old, and lymphadenopathy associated with BCG vaccination was the most common. 2) In culture study of micro-organism, catalase positive microorganisms such as Staphylococcus aureus, Serratia marcescens, Coagulase (-) Staphylococcus, Enterococcus, Proleus vulgaris, Klebsiella pneumoniae, E. coli and fungus such as Candida albicans were isolated. In 2 cases, culture study revealed no growth. 3) Fever, lymphadenopathy, hepatomegaly, suppurative dermatitis and pneumonia were the most common manifestations. In most of cases, antituberculous medications were administered under the impression of tuberculosis without response. 4) Immunologic screening tests including B-cell system, T-cell system, and complement system were within normal limit except NBT test. 5) In spite of severe infections, NBT scores of all the cases were less than those of controls. Liver biopsies of 3 cases showed granuloma formation with characteristic yellow brown pigment-laden macrophages.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pediatrics
/
Pneumonia
/
Serratia marcescens
/
Staphylococcus
/
Staphylococcus aureus
/
Tuberculosis
/
Genetic Variation
/
Biopsy
/
Candida albicans
/
Complement System Proteins
Type of study:
Prognostic study
/
Screening study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
1994
Type:
Article
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