Efficacy of Biodegradable Microneedle Patches on Periorbital Wrinkles / 대한피부과학회지
Korean Journal of Dermatology
;
: 597-607, 2014.
Article
in Korean
| WPRIM
| ID: wpr-170797
ABSTRACT
BACKGROUND:
Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods.OBJECTIVE:
To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement.METHODS:
A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, corneometer, cutometer, and mexameter, respectively (Courage&Khazaka, Cologne, Germany).RESULTS:
Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and corneometer result with statistically significant differences. No significant side effects were noticed.CONCLUSION:
With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Double-Blind Method
/
Follow-Up Studies
/
Patient Satisfaction
/
Epidermal Growth Factor
/
Hyaluronic Acid
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2014
Type:
Article
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