Association of p53 Expression with Metabolic Features of Stage I Non-Small Cell Lung Cancer / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 417-424, 2011.
Article
in English
| WPRIM
| ID: wpr-170820
ABSTRACT
BACKGROUND:
Recent evidences have revealed metabolic functions of p53 in cancer cells; adaptation or survival to metabolic stress and metabolic shift toward oxidative phosphorylation. However, further studies in clinical setting are needed. We investigated whether p53 protein expression, as a surrogate marker for loss of p53 function, is associated with metabolic features of stage I non-small cell lung cancer (NSCLC), focusing on tumor necrosis and maximal standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography.METHODS:
Clinical information was obtained from retrospective review of medical records. p53 expression was assessed by immunohistochemical staining.RESULTS:
p53 protein expression was detected in 112 (46%) of 241 NSCLC cases included in this study. p53 expression was independently associated with the presence of necrosis (odds ratio [OR], 2.316; 95% confidence interval [CI], 1.215~4.416; p=0.011). Non-adenocarcinoma histology (OR, 8.049; 95% CI, 4.072~15.911; p<0.001) and poorly differentiation (OR, 6.474; 95% CI, 2.998~13.979; p<0.001) were also independently associated with the presence of necrosis. However, p53 expression was not a significant factor for SUVmax.CONCLUSION:
p53 protein expression is independently associated with the presence of necrosis, but not SUVmax.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidative Phosphorylation
/
Stress, Physiological
/
Biomarkers
/
Medical Records
/
Retrospective Studies
/
Tumor Suppressor Protein p53
/
Carcinoma, Non-Small-Cell Lung
/
Positron-Emission Tomography
/
Electrons
/
Necrosis
Type of study:
Observational study
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2011
Type:
Article
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