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Association of p53 Expression with Metabolic Features of Stage I Non-Small Cell Lung Cancer / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 417-424, 2011.
Article in English | WPRIM | ID: wpr-170820
ABSTRACT

BACKGROUND:

Recent evidences have revealed metabolic functions of p53 in cancer cells; adaptation or survival to metabolic stress and metabolic shift toward oxidative phosphorylation. However, further studies in clinical setting are needed. We investigated whether p53 protein expression, as a surrogate marker for loss of p53 function, is associated with metabolic features of stage I non-small cell lung cancer (NSCLC), focusing on tumor necrosis and maximal standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography.

METHODS:

Clinical information was obtained from retrospective review of medical records. p53 expression was assessed by immunohistochemical staining.

RESULTS:

p53 protein expression was detected in 112 (46%) of 241 NSCLC cases included in this study. p53 expression was independently associated with the presence of necrosis (odds ratio [OR], 2.316; 95% confidence interval [CI], 1.215~4.416; p=0.011). Non-adenocarcinoma histology (OR, 8.049; 95% CI, 4.072~15.911; p<0.001) and poorly differentiation (OR, 6.474; 95% CI, 2.998~13.979; p<0.001) were also independently associated with the presence of necrosis. However, p53 expression was not a significant factor for SUVmax.

CONCLUSION:

p53 protein expression is independently associated with the presence of necrosis, but not SUVmax.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxidative Phosphorylation / Stress, Physiological / Biomarkers / Medical Records / Retrospective Studies / Tumor Suppressor Protein p53 / Carcinoma, Non-Small-Cell Lung / Positron-Emission Tomography / Electrons / Necrosis Type of study: Observational study Language: English Journal: Tuberculosis and Respiratory Diseases Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxidative Phosphorylation / Stress, Physiological / Biomarkers / Medical Records / Retrospective Studies / Tumor Suppressor Protein p53 / Carcinoma, Non-Small-Cell Lung / Positron-Emission Tomography / Electrons / Necrosis Type of study: Observational study Language: English Journal: Tuberculosis and Respiratory Diseases Year: 2011 Type: Article