A Case of a False-Positive Anti-Myeloperoxidase Antibody ELISA in a Patient with Hypothyroidism / 전남의대학술지
Chonnam Medical Journal
;
: 48-50, 2011.
Article
in English
| WPRIM
| ID: wpr-170941
ABSTRACT
We present a case of a false-positive anti-myeloperoxidase (MPO) antibody result on an ELISA in a patient with anti-thyroid microsomal antibody (TMA)-positive hypothyroidism. A 41-year-old woman presented with dyspnea on exertion. The initial evaluation revealed pericardial effusion associated with hypothyroidism. In addition, microscopic hematuria with normal renal function and positive cytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) on immunofluorescent assay were found. In further evaluation, elevated anti-TMA and MPO antibodies by ELISA. While no definite signs of vasculitis were present, the clinical state improved with thyroid hormone replacement and diuretics. Anti-MPO antibody was still positive in the follow-up tests, and microscopic hematuria persisted. On the basis of previous reports that thyroid peroxidase and MPO molecules contain cross-reactive epitopes that are exposed in denaturated molecules, we suggest that in a patient with anti-TMA-positive hypothyroidism, anti-MPO antibody might also be positive on ELISA without clinical signs of vasculitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pericardial Effusion
/
Thyroid Gland
/
Vasculitis
/
Enzyme-Linked Immunosorbent Assay
/
Follow-Up Studies
/
Antibodies, Antineutrophil Cytoplasmic
/
Cytoplasm
/
Diuretics
/
Dyspnea
/
Hematuria
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Chonnam Medical Journal
Year:
2011
Type:
Article
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