Association between Insulin Resistance and Benign Prostatic Hyperplasia in Healthy Middle-aged Korean Men
Korean Journal of Health Promotion
;
: 202-208, 2015.
Article
in Korean
| WPRIM
| ID: wpr-171048
ABSTRACT
BACKGROUND:
We examined the association between insulin resistance assessed by homeostatic model assessment-insulin resistance (HOMA-IR) and benign prostatic hyperplasia (BPH) in healthy middle-aged male subjects.METHODS:
A cross-sectional study included 1,727 male subjects, aged 40-59 year, free of medication history for BPH who received a transrectal ultrasonography and completed a structured questionnaire in 2011. Multiple logistic regression analysis was performed to evaluate the relationships of HOMA-IR with BPH across the tertile of HOMA-IR.RESULTS:
The prevalence of BPH was 24.4% (421 out of 1,727). It was increased across HOMA-IR tertiles in crude and age-adjusted models. In a multivariable-adjusted model after adjusting potential confounders such as age, body mass index (BMI), triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alcohol consumption, smoking, exercise and meat consumption, odds ratios (95% confidence intervals, CIs) of BPH for 2nd tertile and 3rd tertile compared to 1st tertile were 1.76 (1.31-2.35), and 1.83 (1.34-2.48), respectively.CONCLUSIONS:
In middle-aged, healthy men, higher HOMA-IR was significantly associated with higher prevalence of BPH, supporting insulin resistance as an independent risk factor for BPH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatic Hyperplasia
/
Smoke
/
Triglycerides
/
Alcohol Drinking
/
Insulin Resistance
/
Smoking
/
Body Mass Index
/
Logistic Models
/
Odds Ratio
/
Prevalence
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Qualitative research
/
Risk factors
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Health Promotion
Year:
2015
Type:
Article
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