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Expression levels of heat shock protein 27 and cellular FLICE-like inhibitory protein in prostate cancer correlate with Gleason score sum and pathologic stage
Korean Journal of Urology ; : 505-514, 2015.
Article in English | WPRIM | ID: wpr-171069
ABSTRACT

PURPOSE:

Heat shock protein (HSP) 27 protects the cell by controlling apoptosis and immune reactions, and c-FLIP (cellular-FLICE inhibitory protein) inhibits apoptosis by inhibiting caspase-8 activity. We investigated the relationship of HSP27 and c-FLIP expression to prostate-specific antigen, Gleason score sum (GSS), and pathologic stage. MATERIALS AND

METHODS:

Samples from 163 patients between May 2004 and April 2010 were analyzed 83 from patients that had underwent a radical prostatectomy, and 80 from those that underwent transurethral resection of the prostate to alleviate urinary symptoms from benign prostate hyperplasia. c-FLIP and HSP27 expression were observed by immunohistochemistry staining. Samples with less than 5% expression-positive cells were scored as 1, with 5%-50% were scored as 2, and with more than 50% were scored as 3. Local reactions were identified as 0.5 and evaluated.

RESULTS:

Both the presence of HSP27 within the tumor and the number of cancer cells positive for HSP27 were significantly correlated to GSS and pathologic stage (p<0.001, p=0.001, p<0.001, p<0.001). The same was true for c-FLIP expression (p<0.001). GSS was more highly correlated to HSP27 expression than to c-FLIP expression (r=0.814 for HSP27, r=0.776 for c-FLIP), as was pathologic stage (r=0.592 for HSP27, r=0.554 for c-FLIP).

CONCLUSIONS:

In prostate cancer, higher GSS and a more advanced pathologic stage were associated with a higher likelihood of having a HSP27-positive tumor and more HSP27-positive tumor cells. HSP27 expression was correlated with GSS and prostate cancer stage. A more advanced pathologic stage corresponded to a higher likelihood of having a c-FLIP-positive tumor and more c-FLIP-positive tumor cells. HSP27 expression had a higher correlation with prostate cancer stage and GSS than c-FLIP expression did.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prostatectomy / Prostatic Hyperplasia / Prostatic Neoplasms / Biomarkers, Tumor / Transurethral Resection of Prostate / CASP8 and FADD-Like Apoptosis Regulating Protein / HSP27 Heat-Shock Proteins / Neoplasm Grading / Lymphatic Metastasis / Neoplasm Proteins Type of study: Prognostic study Limits: Aged / Humans / Male Language: English Journal: Korean Journal of Urology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prostatectomy / Prostatic Hyperplasia / Prostatic Neoplasms / Biomarkers, Tumor / Transurethral Resection of Prostate / CASP8 and FADD-Like Apoptosis Regulating Protein / HSP27 Heat-Shock Proteins / Neoplasm Grading / Lymphatic Metastasis / Neoplasm Proteins Type of study: Prognostic study Limits: Aged / Humans / Male Language: English Journal: Korean Journal of Urology Year: 2015 Type: Article