The clinicopathological relevance for the expression of cyclin E, CDK2, and p27 in endometrial carcinoma / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 1112-1120, 2008.
Article
in Korean
| WPRIM
| ID: wpr-171109
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the clinicopathological relevance for the expression of cyclin E, CDK2 and p27 in endometrial carcinoma.METHODS:
With a retrospective review, slide samples (n=71) were analyzed. All patients had been treated with hysterectomy from January 1998 to December 2006. The expression of cyclin E, CDK2 and p27 were analyzed using immunohistochemical staining.RESULTS:
Of 71 cases, the positive expression was cyclin E; 28 cases (39.4%), CDK2; 29 cases (40.8%). The expression of cyclin E showed positive correlation with lymph node metastasis (P=0.033) and estrogen receptor. The expression of CDK2 showed positive correlation with estrogen receptor (P=0.000). The negative expression of p27 was 42 cases (59.2%) and showed no correlation with other clinicopathological factors. Cyclin E overexpression with loss of p27 expression showed positive correlation with advanced stage (P=0.002), lymphovascular invasion (P=0.030) and lymph node metastasis (P=0.002).CONCLUSION:
Cyclin E overexpression with loss of p27 expression could be an useful negative prognostic factors for endometrial carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retrospective Studies
/
Endometrial Neoplasms
/
Cyclins
/
Cyclin E
/
Estrogens
/
Hysterectomy
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2008
Type:
Article
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