Unusual Involvement of IgG4-Related Sclerosing Disease in Lacrimal and Submandibular Glands and Extraocular Muscles
Korean Journal of Ophthalmology
;
: 216-221, 2012.
Article
in English
| WPRIM
| ID: wpr-171218
ABSTRACT
Chronic sclerosing sialadenitis, also known as Kuttner tumor, is a chronic inflammatory disease of the salivary glands that is reported in a few cases in medical literature. Recent reports suggest that certain aspects of sclerosing diseases, including chronic sclerosing sialadenitis or dacryoadenitis, should be classified under immunoglobulin G4 (IgG4)-related sclerosing disease based on immunohistochemical studies. This study reports an unusual case of IgG4-related sclerosing disease appearing simultaneously in the lacrimal glands, submandibular glands, and extraocular muscles. A 56-year-old male presented with complaints of bilateral eyelid swelling and proptosis that began two years ago. Computed tomography confirmed that bilateral submandibular enlargements also existed five years ago in the subject. Orbital computed tomography and magnetic resonance imaging revealed bilateral lacrimal gland enlargement and thickening of extraocular muscles. Typical findings of chronic sclerosing dacryoadenitis were revealed upon pathologic exam of the right lacrimal gland. Immunostaining revealed numerous IgG4-positive plasma cells. Through these clinical features, we make a diagnosis of IgG4-relataed sclerosing disease in the subject.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sclerosis
/
Submandibular Gland
/
Submandibular Gland Diseases
/
Immunoglobulin G
/
Immunohistochemistry
/
Magnetic Resonance Imaging
/
Tomography, X-Ray Computed
/
Follow-Up Studies
/
Biopsy, Fine-Needle
/
Diagnosis, Differential
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
2012
Type:
Article
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