Association of p53 Protein Expression with Clinical Outcome in Advanced Supraglottic Cancer / 대한방사선종양학회지
The Journal of the Korean Society for Therapeutic Radiology and Oncology
;
: 1-6, 1998.
Article
in Korean
| WPRIM
| ID: wpr-17123
ABSTRACT
PURPOSE:
To determine the incidence and prognostic effect of p53 expression in patients with advanced supraglottic cancer. MATERIALS ANDMETHODS:
Twenty-one cases of total 48 advanced supraglottic cancer patients who received postoperative adjuvant radiation therapy were evaluated by immunohistochemical staining employing p53 monoclonal antibody.RESULT:
Three out of six stage III patients and four out of fifteen stage IV patients showed p53 expression without statistically significant difference (P=0.608). Five year survival rates are 93% in p53 negative, 86% in p53 positive patients and there was no significant difference (P=0.776). p53 expression does not show statistically significant correlation with primary tumor status (P=0.877), lymph node status (P=0.874) and age (P=0.64).CONCLUSION:
There was no statistically significant correlation between traditionally known risk factors and p53 expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Incidence
/
Survival Rate
/
Risk Factors
/
Lymph Nodes
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Society for Therapeutic Radiology and Oncology
Year:
1998
Type:
Article
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