The effects of epidural magnesium on postoperative pain management in patients with patient-controlled epidural analgesia after a thoracotomy / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 466-471, 2009.
Article
in Korean
| WPRIM
| ID: wpr-171241
ABSTRACT
BACKGROUND:
Magnesium presents analgesic effects by blocking the non-competitive N-methyl-D-aspartate receptor in the spinal cord. The purpose of this study was to evaluate the effects of epidural magnesium on cumulative dose of ropivacaine in patients with patient-controlled epidural analgesia (PCEA) after a thoracotomy.METHODS:
In a randomized, prospective, double-blind trial, we enrolled 40 patients undergoing PCEA after a thoracotomy. Control group (n = 20) received an initial dose of 0.375% ropivacaine 0.1 ml/kg, and following demand doses of 0.2% ropivacaine 2 ml with 15 min lockout interval on the patient demand. Magnesium group (n = 20) additionally received MgSO4 100 mg in the initial dose and 4 mg in the demand doses. Cumulative dose of ropivacaine, the resting and coughing visual analog scale (VAS) score were measured at 3, 6, 12, 24, and 48 hours after surgery.RESULTS:
Magnesium group showed lower cumulative dose of ropivacaine than control group at 12, 24, and 48 hours after the surgery (P<0.05), but not at 3 and 6 hours (P < 0.05). The VAS score was not different between 2 groups (P < 0.05).CONCLUSIONS:
Epidural magnesium may be useful as an adjuvant to ropivacaine after a thoracotomy. However, because magnesium showed no beneficial effect at the early period after the surgery, more investigation about proper initial dose is required.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain, Postoperative
/
Spinal Cord
/
Thoracotomy
/
Analgesia, Epidural
/
Prospective Studies
/
Analgesia, Patient-Controlled
/
N-Methylaspartate
/
Cough
/
Amides
/
Magnesium
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2009
Type:
Article
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