Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser
Annals of Dermatology
;
: 457-463, 2016.
Article
in English
| WPRIM
| ID: wpr-171608
ABSTRACT
BACKGROUND:
The survival and growth of melanocytes are controlled by the binding of stem cell factor to its cell surface receptor c-kit+ (CD117). We have observed that c-kit+ melanocytes existed in some lesions of vitiligo, while Melan A+ cells were absent.OBJECTIVE:
To verify possible relation between c-kit+ expression and treatment response in non-segmental vitiligo lesions.METHODS:
Skin biopsies were done from the center of the 47 lesions from the 47 patients with non-segmental vitiligo. Expression of c-kit+ and Melan A, and amounts of melanin in the epidermis were assessed in each lesion, and treatment responses to excimer laser were evaluated.RESULTS:
Thirty-five of the 47 lesions (74.5%) had c-kit+ phenotypes. There was significant difference of c-kit staining value between good responders in 3 months of excimer laser treatment (average of 24 sessions) and the others.CONCLUSION:
c-Kit expression in vitiliginous epidermis may be related to better treatment responses to excimer laser.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Skin
/
Vitiligo
/
Biopsy
/
Stem Cell Factor
/
Proto-Oncogene Proteins c-kit
/
Epidermis
/
Lasers, Excimer
/
MART-1 Antigen
/
Melanins
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2016
Type:
Article
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