Glutathione S-transferase Gene Polymorphisms and Systemic Lupus Erythematosus / 대한류마티스학회지

ABSTRACT

OBJECTIVE: To determine whether GSTM1, GSTT1 and GSTP1 polymorphisms are associated with susceptibility or disease manifestations in patients with SLE. METHODS: Two hundred eighty-six SLE patients who fulfilled the American College of Rheumatology (ACR) criteria were compared with 271 cases of age and sex matched controls to examine association between GST genotypes and susceptibility to SLE. The effect of genotype on SLE manifestations was assessed using the comparison of ACR diagnostic criteria. GST gene polymorphisms were determined by a multiplex polymerase chain reaction and antibodies to SS-A and SS-B were determined by double immunodiffusion. RESULTS: No association was found in the comparison of GSTM1 null, GSTT1 null, GSTP1 Ile105--patients and the controls. GSTM1 null SLE patients had a lower frequency of hematologic disorder than GSTM1 non-null SLE patients (p=0.026). SLE patients with SS-A (+)/SS-B (-) antibody profile had a higher frequency of GSTM1 null compared to the controls (p=0.024). GSTT1 null SLE patients had a lower frequency of discoid rash (p=0.049) and nephritis (p=0.050) compared to the GSTT1 non-null SLE patients. SLE patients with non-null for both GSTM1 and GSTT1 had a higher frequency of lympophenia compared to the other genotypes (p=0.006). SLE patients with GSTP1 heterozygote mutant genotype (Ile105/Val105) had a higher frequency of psychosis compared to the other genotypes.

CONCLUSION:

GSTM1 null, GSTT1 null, GSTP1 Ile105--gene polymorphisms influence some SLE disease manifestations. Our data suggest that oxidative damages and its detoxification efficacy might play an important role in determining the disease manifestations in patients with SLE.