Perfusion MR Imaging in Gliomas: Comparison with Histologic Tumor Grade
Korean Journal of Radiology
;
: 1-7, 2001.
Article
in English
| WPRIM
| ID: wpr-171865
ABSTRACT
OBJECTIVE:
To determine the usefulness of perfusion MR imaging in assessing the histologic grade of cerebral gliomas. MATERIALS ANDMETHODS:
In order to determine relative cerebral blood volume (rCBV), 22 patients with pathologically proven gliomas (9 glioblastomas, 9 anaplastic gliomas and 4 low-grade gliomas) underwent dynamic contrast-enhanced T2*-weighted and conventional T1- and T2-weighted imaging. rCBV maps were obtained by fitting a gamma-variate function to the contrast material concentration versus time curve. rCBV ratios between tumor and normal white matter (maximum rCBV of tumor / rCBV of contralateral white matter) were calcu-lated and compared between glioblastomas, anaplastic gliomas and low-grade gliomas.RESULTS:
Mean rCBV ratios were 4.90'+/-1.01 for glioblastomas, 3.97'+/-0.56 for anaplastic gliomas and 1.75'+/-1.51 for low-grade gliomas, and were thus sig-nificantly different; p < .05 between glioblastomas and anaplastic gliomas, p <.05 between anaplastic gliomas and low-grade gliomas, p < .01 between glioblas-tomas and low-grade gliomas. The rCBV ratio cutoff value which permitted dis-crimination between high-grade (glioblastomas and anaplastic gliomas) and low-grade gliomas was 2.60, and the sensitivity and specificity of this value were 100% and 75%, respectively.CONCLUSION:
Perfusion MR imaging is a useful and reliable technique for esti-mating the histologic grade of gliomas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Astrocytoma
/
Brain
/
Brain Neoplasms
/
Magnetic Resonance Imaging
/
Cerebrovascular Circulation
/
Glioblastoma
/
Contrast Media
/
Gadolinium DTPA
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Radiology
Year:
2001
Type:
Article
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