Effect of Carvedilol on the Growth of Vascular Smooth Muscle Cells
Korean Circulation Journal
;
: 1583-1589, 1998.
Article
in Korean
| WPRIM
| ID: wpr-171908
ABSTRACT
Background and objectives:
Carvedilol is a cardiovascular drug, beta- and alpha1-adrenoceptor antagonist, currently approved for the treatment of hypertension, angina, congestive heart failure by FDA. Carvedilol has been shown to attenuate oxygen free radical-initiated lipid peroxidation and to inhibit neointimal formation of aorta following vascular injury by balloon angioplasty. We have investigated the effect of carvedilol on DNA synthesis of vascular smooth muscle cells (VSMC) stimulated by platelet-derived growth factor (PDGF)-BB. MATERIALS ANDMETHOD:
Rat aortic smooth muscle cells were obtained by the combined collagenase and elastase methods. Cells between the 4th and 8th passages were used for the experiments. Incorporated radioactivity of [3H]-thymidine was measured by liquid scintillation spectrometry.RESULTS:
PDGF-BB (1 nM) increased [3H]-thymidine incorporation about 70-100% over basal value in cultured VSMC. PDGF-stimulated increase in DNA synthesis was significantly suppressed by simultaneous administration of carvedilol. In contrast, propranolol did not significantly affect 3[H]-thymidine uptake in rat aortic VSMC.CONCLUSION:
The present study demonstrate that carvedilol significantly inhibits the proliferation of vascular smooth muscle cell in our condition. These results indicate that carvedilol may be effective in the treatment of cardiovascular diseases principally associated with abnormal vascular smooth muscle growth.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta
/
Oxygen
/
Propranolol
/
Radioactivity
/
Spectrum Analysis
/
DNA
/
Platelet-Derived Growth Factor
/
Pancreatic Elastase
/
Cardiovascular Diseases
/
Lipid Peroxidation
Limits:
Animals
Language:
Korean
Journal:
Korean Circulation Journal
Year:
1998
Type:
Article
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