Optimal effect-site concentration of remifentanil for preventing development of hypertension during tracheal intubation with inhaled desflurane induction / 대한마취과학회지
Korean Journal of Anesthesiology
; : 8-11, 2011.
Article
in En
| WPRIM
| ID: wpr-171972
Responsible library:
WPRO
ABSTRACT
BACKGROUND: The aim of the present study was to determine the effect-site concentration of remifentanil needed to prevent haemodynamic instability during tracheal intubation with inhaled desflurane induction. METHODS: One hundred American Society of Anesthesiologists I and II female patients were randomized to receive an effect-site concentration of remifentanil of 0, 1, 2, 3, or 4 ng/ml. Induction of anaesthesia was started with intravenous injection of propofol 2 mg/kg. Ninety seconds after the completion of propofol injection, rocuronium (0.8 mg/kg) and remifentanil were administered simultaneously with 3% desflurane inhalation. Tracheal intubation was attempted 150 sec after the commencement of remifentanil administration. RESULTS: A probit model of remifentanil concentration was predictive of successful intubation without development of hypertension (P for goodness-of-fit = 0.419). The effect-site concentration of remifentanil needed to achieve successful intubation without development of hypertension in 95% of the patients was 3.3 ng/ml (95% confidence interval, 2.6-4.8 ng/ml). CONCLUSIONS: The effect-site concentration of remifentanil of 3.3 ng/ml is effective in blunting the haemodynamic response in 95% of the patients when 2.0 mg/kg of propofol induction was followed by 3% desflurane inhalation.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Piperidines
/
Propofol
/
Inhalation
/
Hypertension
/
Androstanols
/
Injections, Intravenous
/
Intubation
/
Isoflurane
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Korean Journal of Anesthesiology
Year:
2011
Type:
Article