The Relationship of Insulin Resistance to High-Sensitivity C-Reactive Protein / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 465-470, 2001.
Article
in Korean
| WPRIM
| ID: wpr-172170
ABSTRACT
BACKGROUND:
Insulin resistance is known as the common denominator of risk factors of atheros-clerosis as well as the major pathogenic process of type 2 diabetes mellitus (DM). Recently some investigators indicated the relationship of chronic inflammatory reaction to atherosclerosis and insulin resistance. We examined the relationship between insulin resistance and high sensitivity CRP (hs-CRP) in Koreans.METHODS:
Twenty-five patients with type 2 DM and eleven healthy men were examined. Glucose disposal rate (GDR, mg/kg/min) was determined as the index of insulin resistance by the euglycemic insulin clamp test with De Fronzo method. The serum hs-CRP level was determined by Behring nephelometric assay, fibrinogen by functional assay, and plasminogen activator inhibitor-1 (PAI-1) by ELISA. We also included 81 healthy subjects to determine the reference range of hs-CRP.RESULTS:
The reference range (median) of hs-CRP was 0-5.20 (0.56) mg/L. The hs-CRP concentration was not significantly different between control and DM groups. The GDR of DM (3.8+/-1.7) showed significantly decreased value compared with normal (8.4+/-1.5) group (P<0.001). In all subjects, there was no significant correlation of GDR and hs-CRP. CONCLUSTIONS There was no significant correlation of GDR and hs-CRP. We think the interventional prospective study with anti-inflammatory drug is warranted to elucidate the independent relationship between insulin resistance and hs-CRP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Research Personnel
/
C-Reactive Protein
/
Fibrinogen
/
Insulin Resistance
/
Enzyme-Linked Immunosorbent Assay
/
Plasminogen Activators
/
Risk Factors
/
Diabetes Mellitus, Type 2
/
Atherosclerosis
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Risk factors
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Clinical Pathology
Year:
2001
Type:
Article
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