Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 358-366, 2011.
Article
in English
| WPRIM
| ID: wpr-172277
ABSTRACT
During the past few decades, a large number of animal studies demonstrated that commonly used opioids could provide cardioprotection against ischemia-reperfusion (I/R) injury. Opioid-induced preconditioning or postconditioning mimics ischemic preconditioning (I-Pre) or ischemic postconditioning (I-Post). Both delta- and kappa-opioid receptors (OPRs) play a crucial role in opioid-induced cardioprotection (OIC). Down stream signaling effectors of OIC include ATP-sensitive potassium (KATP) channels, protein kinase C (PKC), tyrosine kinase, phosphatidylinositol-3-kinase (PI3-kinase), extracellular signal regulated kinase1/2 (ERK1/2), glycogen synthase kinase-3beta (GSK-3beta), and mitochondrial permeability transition pore (MPTP), among others. Recently, various reports also suggest that opioids could provide cardioprotection in humans. This review will discuss OIC using mostly morphine and remifentanil which are widely used during cardiac anesthesia in addition to the clinical implications of OIC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Piperidines
/
Potassium
/
Protein Kinase C
/
Protein-Tyrosine Kinases
/
Myocardial Reperfusion
/
Glycogen Synthase
/
Myocardial Ischemia
/
Ischemic Preconditioning
/
Mitochondrial Membrane Transport Proteins
Limits:
Animals
/
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2011
Type:
Article
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