Blood Brain Barrier and Brain Tissue Injury by Gd-DTPA in Uremia-induced Rabbits
Journal of the Korean Radiological Society
;
: 837-846, 1996.
Article
in Korean
| WPRIM
| ID: wpr-172380
ABSTRACT
PURPOSE:
An experimental study was carried out to evaluate the morphological changes in the blood brain barrier and neighbouring brain tissue caused by Gd-DTPA in uremia-induced rabbits. MATERIALS ANDMETHODS:
Bilateral renal arteries and veins of ten rabbits were ligated. Gd-DTPA(0.2 mmol/kg) was intravenously injectedinto seven rabbits immediately after ligation. After MRI, they were sacrificed 2 or 3 days after ligation in orderto observe light and electron microscopic changes in the blood brain barrier and brain tissue.RESULTS:
MRIfindings were normal, except for enhancement of the superior and inferior sagittal sinuses on T1 weighted imagesin uremia-induced rabbits injected with Gd-DTPA. On light microscopic examination, these rabbits showed perivascular edema and glial fibrillary acidic protein expression ; electron microscopic examination showed separation of tight junctions of endothelial cells, duplication/rarefaction of basal lamina, increased lysosomes of neurons with neuronal death, demyelination of myelin, and extravasation of red blood cells. Uremia-induced rabbits injected with Gd-DTPA showed more severe changes than those without Gd-DTPA injection.CONCLUSION:
Injuries to the blood brain barrier and neighbouring brain tissue were aggravated by Gd-DTPA administration inuremia-induced rabbits. These findings appear to be associated with the neurotoxicity of Gd-DTPA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Renal Artery
/
Basement Membrane
/
Veins
/
Brain
/
Brain Injuries
/
Magnetic Resonance Imaging
/
Blood-Brain Barrier
/
Demyelinating Diseases
/
Tight Junctions
/
Gadolinium DTPA
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Radiological Society
Year:
1996
Type:
Article
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