Feasibility of sentinel lymph node dissection using Tc-99m phytate in papillary thyroid carcinoma
Annals of Surgical Treatment and Research
;
: 240-245, 2017.
Article
in English
| WPRIM
| ID: wpr-172617
ABSTRACT
PURPOSE:
Various methods of sentinel lymph node (SLN) biopsy in thyroid cancer have been introduced. Tc-99m phytate as a radiotracer has been successfully utilized for SLN biopsy in breast, cervix, and endometrial cancer. We assessed the feasibility of SLN dissection using Tc-99m phytate in papillary thyroid carcinoma (PTC).METHODS:
Seventeen patients with PTC were prospectively enrolled. Ultrasound-guided peritumoral injection of 55.5 MBq Tc-99m phytate in 0.25-mL normal saline was performed. Preoperative single-photon emission-computed tomography (SPECT) and intraoperative gamma-probe were used for SLN detection during operation.RESULTS:
Identification rate of SLNs was 70.6% (12 of 17) with SPECT, and 88.2% (15 of 17) with gamma-probe. Combined SPECT and gamma-probe had identification rates of 88.2% (15 of 17). Identification rates of SLNs in central LN compartments were 82.4% (14 of 17) and 41.2% (7 of 17) in lateral LN compartments. Overall sensitivity, specificity, positive predictive value, and negative predictive value of the results of SLN biopsy were 91.6%, 100%, 88.4%, and 100%, respectively. Eight patients (47.1%) had metastasis in SLNs; all patients had SLN metastasis in the central compartment and 2 patients had SLN metastasis in both the central and lateral compartments.CONCLUSION:
Combined SPECT and gamma-probe could detect SLNs with an 88.2% identification rate in PTC. SLN biopsy using Tc-99m phytate is technically feasible. Further investigation is warranted for clinical application of Tc-99m phytate in PTC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phytic Acid
/
Thyroid Gland
/
Biopsy
/
Breast
/
Thyroid Neoplasms
/
Tomography, Emission-Computed, Single-Photon
/
Cervix Uteri
/
Prospective Studies
/
Sensitivity and Specificity
/
Endometrial Neoplasms
Type of study:
Diagnostic study
/
Observational study
Limits:
Female
/
Humans
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2017
Type:
Article
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