Small Dose of Midazolam Added to Fentanyl-Ropivacaine for Patient Controlled Epidural Analgesia after Subtotal Gastrectomy
Anesthesia and Pain Medicine
;
: 22-26, 2008.
Article
in English
| WPRIM
| ID: wpr-173149
ABSTRACT
BACKGROUND:
Midazolam has been reported to have a spinally mediated antinociceptive effect. In this randomized, double-blind study, we evaluated whether a small dose of midazolam added to fentanyl-ropivacaine mixture for PCEA (patient controlled epidural analgesia) improves epidural analgesia in patients underwent elective subtotal gastrectomy.METHODS:
Forty five patients, ASA physical status I and II, undergoing subtotal gastrectomy were randomly allocated to receive 0.2% ropivacaine mixed with fentanyl 4microg/ml or 0.2% ropivacaine mixed with fentanyl 4microg/ml and midazolam 0.2 mg/ml. The infusion rate was set to deliver 4 ml/hr of the study solution, with a bolus of 2 ml per demand and a 20 minutes lockout time.RESULTS:
Infused volume (P < 0.05) and VAS scores (P < 0.05) was significantly lower in the patients receiving midazolam. However, there were no differences in requiring rescue analgesics, PONV (postoperative nausea and vomiting), sedation scores, urinary retention, and pruritus between groups.CONCLUSIONS:
Small dose of midazolam could augment analgesia without adverse effects when added to thoracic epidural infusion of fentanyl and ropivacaine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pruritus
/
Midazolam
/
Analgesia, Epidural
/
Fentanyl
/
Double-Blind Method
/
Urinary Retention
/
Postoperative Nausea and Vomiting
/
Amides
/
Gastrectomy
/
Analgesia
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Anesthesia and Pain Medicine
Year:
2008
Type:
Article
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