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Effect of Helicobacter pylori Eradication on Subsequent Dysplasia Development after Endoscopic Resection of Gastric Dysplasia / 대한소화기학회지
The Korean Journal of Gastroenterology ; : 307-312, 2013.
Article in English | WPRIM | ID: wpr-173421
ABSTRACT
BACKGROUND/

AIMS:

Eradication of Helicobacter pylori reduces the incidence of gastric cancer, and may inhibit gastric dysplasia progression into gastric cancer. The aim of this study was to investigate the effect of eradication of Helicobacter on the incidence of subsequent gastric dysplasia development after endoscopic resection.

METHODS:

Medical records of patients who underwent endoscopic resection for gastric dysplasia were retrospectively reviewed. Presence of H. pylori was assessed by the Campylobacter-like organism test and histology. The rate of subsequent dysplasia development after endoscopic resection between the eradication group and non-eradication group was compared.

RESULTS:

Total of 129 patients positive for H. pylori infection were included for analysis. Of these, 85 patients received successful eradication therapy and 44 patients did not receive eradication therapy or failed to achieve successful eradication. Sex, mean age and pathologic grade of dysplasia did not differ between the two groups. In univariate analysis, the grade of intestinal metaplasia (p=0.013) significantly differed between metachronous dysplasia group and non-metachrounous dysplasia group. In multivariate analysis, eradication of H. pylori (p=0.014) was related to reduced incidence of subsequent gastric dysplasia development after endoscopic resection.

CONCLUSIONS:

Eradication of H. pylori likely has a beneficial effect in preventing the development of subsequent gastric dysplasia, a premalignant lesion of gastric cancer, after endoscopic resection.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Precancerous Conditions / Stomach Neoplasms / Proportional Hazards Models / Retrospective Studies / Helicobacter pylori / Helicobacter Infections / Gastroscopy / Gastric Mucosa / Metaplasia / Anti-Bacterial Agents Type of study: Observational study Limits: Aged / Female / Humans / Male Language: English Journal: The Korean Journal of Gastroenterology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Precancerous Conditions / Stomach Neoplasms / Proportional Hazards Models / Retrospective Studies / Helicobacter pylori / Helicobacter Infections / Gastroscopy / Gastric Mucosa / Metaplasia / Anti-Bacterial Agents Type of study: Observational study Limits: Aged / Female / Humans / Male Language: English Journal: The Korean Journal of Gastroenterology Year: 2013 Type: Article