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Central Pontine Myelinolysis in a Patient with Acute Lymphoblastic Leukemia after Hematopoietic Stem Cell Transplantation: A Case Report
Journal of Korean Medical Science ; : 324-327, 2008.
Article in English | WPRIM | ID: wpr-173545
ABSTRACT
We describe a 37-yr-old man who developed central pontine myelinolysis (CPM) after allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia. After HSCT, desquamation developed on the whole body accompanied by hyperbilirubinemia. The liver biopsy of the patient indicated graft-versus-host disease- related liver disease, and the dose of methylprednisolone was increased. Then, the patient developed altered mentality with eye ball deviation to the left, for which electroencephalogram and magnetic resonance imaging (MRI) scans were done. Brain MRI scan demonstrated the imaging findings consistent with central pontine myelinolysis and extrapontine myelinolysis. He did not have any hyponatremia episode during hospitalization prior to the MRI scan. To the best of our knowledge, presentation of CPM after allogeneic HSCT is extremely rare in cases where patients have not exhibited any episodes of significant hyponatremia. We report a rare case in which hepatic dysfunction due to graft-versus-host disease has a strong association with CPM after HSCT.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Biopsy / Brain / Magnetic Resonance Imaging / Treatment Outcome / Myelinolysis, Central Pontine / Hematopoietic Stem Cell Transplantation / Electroencephalography / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Graft vs Host Disease Limits: Adult / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Biopsy / Brain / Magnetic Resonance Imaging / Treatment Outcome / Myelinolysis, Central Pontine / Hematopoietic Stem Cell Transplantation / Electroencephalography / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Graft vs Host Disease Limits: Adult / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2008 Type: Article