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Onion peel extract reduces the percentage of body fat in overweight and obese subjects: a 12-week, randomized, double-blind, placebo-controlled study
Nutrition Research and Practice ; : 175-181, 2016.
Article in English | WPRIM | ID: wpr-173778
ABSTRACT
BACKGROUND/

OBJECTIVES:

The anti-obesity effect of quercetin-rich onion peel extract (OPE) was suggested in rats, but information from human studies is limited. This study aimed to investigate the effects of OPE on the body composition of overweight and obese subjects. MATERIALS/

METHODS:

In this 12-week, randomized, double-blind, placebo-controlled study, parallel clinical trials were performed in overweight and obese Korean subjects. Randomly assigned subjects were instructed to take daily either the placebo (male, 6 and female, 30) or OPE capsules containing 100 mg of quercetin (male, 5 and female, 31). Body composition was measured by using bioimpedance and dual-energy X-ray absorptiometry (DXA). Resting energy expenditure (REE) and respiratory quotient (RQ) were evaluated by using indirect calorie measurement methods. Fasting blood levels of glucose, insulin, lipids, and leptin were determined.

RESULTS:

Quercetin-rich OPE supplementation significantly reduced the weight and percentage of body fat as measured by DXA (P = 0.02). These effects were not shown in the control group. Levels of blood glucose (P = 0.04) and leptin (P = 0.001 for placebo, P = 0.002 for OPE) decreased in both groups. Significant increases in REE and RQ were observed in both groups (P = 0.003 for placebo, P = 0.006 for OPE) and in the OPE group alone (P = 0.02), respectively.

CONCLUSIONS:

Quercetin-rich OPE supplementation changed the body composition of the overweight and obese subjects. This result suggests a beneficial role of the anti-obesity effect of OPE human subjects.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Quercetin / Blood Glucose / Body Composition / Capsules / Absorptiometry, Photon / Adipose Tissue / Fasting / Onions / Leptin / Energy Metabolism Type of study: Controlled clinical trial Limits: Animals / Female / Humans Language: English Journal: Nutrition Research and Practice Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quercetin / Blood Glucose / Body Composition / Capsules / Absorptiometry, Photon / Adipose Tissue / Fasting / Onions / Leptin / Energy Metabolism Type of study: Controlled clinical trial Limits: Animals / Female / Humans Language: English Journal: Nutrition Research and Practice Year: 2016 Type: Article