Clinical Significance of a Large Difference (> or = 2 points) between Biopsy and Post-prostatectomy Pathological Gleason Scores in Patients with Prostate Cancer
Journal of Korean Medical Science
;
: 507-512, 2011.
Article
in English
| WPRIM
| ID: wpr-173913
ABSTRACT
We investigated the clinical significance of large difference (> or = 2 points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups A (decreased in pGS > or = 2, n = 30), B (changed in pGS or = 2, n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max%) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max% were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (P = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Prostatectomy
/
Prostatic Neoplasms
/
Recurrence
/
Biopsy
/
Severity of Illness Index
/
Multivariate Analysis
/
Age Factors
/
Neoplasm Staging
Type of study:
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2011
Type:
Article
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