Antimicrobial Effects of Ursolic Acid against Mutans Streptococci Isolated from Koreans
International Journal of Oral Biology
;
: 7-11, 2011.
Article
in English
| WPRIM
| ID: wpr-173921
ABSTRACT
Ursolic acid is a triterpenoid compound present in many plants. This study examined the antimicrobial activity of ursolic acid against mutans streptococci (MS) isolated from the Korean population. The antimicrobial activity was evaluated by the minimum inhibitory concentration (MIC) and time kill curves of MS. The cytotoxicity of ursolic acid against KB cells was tested using an MTT assay. The MIC90 values of ursolic acid for Streptococcus mutans and Streptococcus sobrinus isolated from the Korean population were 2 microg/ml and 4 microg/ml, respectively. Ursolic acid had a bactericidal effect on S. mutans ATCC 25175T and S. sobrinus ATCC 33478T at > 2 x MIC (4 microg/ml) and 4 x MIC (8 microg/ml), respectively. Ursolic acid had no cytotoxic effect on KB cells at concentrations at which it exerted antimicrobial effects. The results suggest that ursolic acid can be used in the development of oral hygiene products for the prevention of dental caries.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oral Hygiene
/
Streptococcus mutans
/
Triterpenes
/
KB Cells
/
Microbial Sensitivity Tests
/
Streptococcus sobrinus
/
Dental Caries
Limits:
Humans
Language:
English
Journal:
International Journal of Oral Biology
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS