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Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma
Article in English | WPRIM | ID: wpr-17407
Responsible library: WPRO
ABSTRACT
In this work, we used a preparation of diminazene, which belongs to the group of aromatic diamidines. This compound acts on the causative agents of blood protozoan diseases produced by both flagellated protozoa (Trypanosoma) and members of the class Piroplasmida (Babesia, Theileria, and Cytauxzoon) in various domestic and wild animals, and it is widely used in veterinary medicine. We examined the behavior of water-disperse diminazene (immobilized in Tween 80 micelles) at the cellular and organismal levels. We assessed the interaction of an aqueous and a water-disperse preparation with cells of the reticuloendothelial system. We compared the kinetic parameters of aqueous and water-disperse diminazene in sheep erythrocytes and plasma. The therapeutic properties of these two preparations were also compared. We found that the surface-active substances improved intracellular penetration of the active substance through interaction with the cell membrane. In sheep blood erythrocytes, micellar diminazene accumulated more than its aqueous analog. This form was also more effective therapeutically than the aqueous analog. Our findings demonstrate that use of micellar diminazene allows the injection dose to be reduced by 30%.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Polysorbates / Rats / Sheep Diseases / Babesiosis / Trypanocidal Agents / Female / Male / Sheep / Macrophages, Peritoneal / Diminazene Language: English Journal: Journal of Veterinary Science Year: 2011 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polysorbates / Rats / Sheep Diseases / Babesiosis / Trypanocidal Agents / Female / Male / Sheep / Macrophages, Peritoneal / Diminazene Language: English Journal: Journal of Veterinary Science Year: 2011 Type: Article