The relationship between muscle mitochondrial nutritional overloading and insulin resistance / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 19-28, 2017.
Article
in English
| WPRIM
| ID: wpr-174152
ABSTRACT
The incidence of type 2 diabetes mellitus and insulin resistance is growing rapidly. Multiple organs including the liver, skeletal muscle and adipose tissue control insulin sensitivity coordinately, but the mechanism of skeletal muscle insulin resistance has not yet been fully elucidated. However, there is a growing body of evidence that lipotoxicity induced by mitochondrial dysfunction in skeletal muscle is an important mediator of insulin resistance. However, some recent findings suggest that skeletal mitochondrial dysfunction generated by genetic manipulation is not always correlated with insulin resistance in animal models. A high fat diet can provoke insulin resistance despite a coordinate increase in skeletal muscle mitochondria, which implies that mitochondrial dysfunction is not mandatory in insulin resistance. Furthermore, incomplete fatty acid oxidation by excessive nutrition supply compared to mitochondrial demand can induce insulin resistance without preceding impairment of mitochondrial function. Taken together we suggested that skeletal muscle mitochondrial overloading, not mitochondrial dysfunction, plays a pivotal role in insulin resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Insulin Resistance
/
Adipose Tissue
/
Incidence
/
Reactive Oxygen Species
/
Muscle, Skeletal
/
Models, Animal
/
Diabetes Mellitus, Type 2
/
Diet, High-Fat
/
Insulin
/
Liver
Type of study:
Incidence study
/
Prognostic study
Language:
English
Journal:
Yeungnam University Journal of Medicine
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS