The Influence of the Severity of Chronic Virus-Related Liver Disease on Propofol Requirements during Propofol-Remifentanil Anesthesia
Yonsei Medical Journal
;
: 231-237, 2013.
Article
in English
| WPRIM
| ID: wpr-17424
ABSTRACT
PURPOSE:
The purpose of this study was to investigate the influence of chronic virus-related liver disease severity on propofol requirements. MATERIALS ANDMETHODS:
In this study, 48 male patients with chronic hepatitis B infection were divided into three groups according to Child-Turcotte-Pugh classification of liver function (groups A, B, and C with mild, moderate and severe liver disease, respectively). After intubation, propofol concentration was adjusted by +/-0.3 microg/mL increments to maintain bispectral index in the range of 40-60. Target propofol concentrations at anesthesia initiation, pre-intubation and pre-incision were recorded.RESULTS:
The initial concentration used in group C was significantly lower than that used in group A or B (p<0.05), whereas no difference was observed between groups A and B. At pre-intubation, the actual required concentration of propofol increased significantly (3.2 microg/mL) in group A (p<0.05), which lead to significant differences between the groups (p<0.05). At pre-incision, the requirements for propofol decreased significantly in both groups A and B (3.0 microg/mL and 2.7 microg/mL, respectively) compared with those at pre-intubation (p<0.05), and were significantly different for all three groups (p<0.05), with group C demonstrating the lowest requirement (2.2 microg/mL). The required concentrations of propofol at pre-incision were similar to those at induction.CONCLUSION:
In this study, propofol requirements administered by target-controlled infusion to maintain similar depths of hypnosis were shown to depend on the severity of chronic virus-related liver dysfunction. In other words, patients with the most severe liver dysfunction required the least amount of propofol.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperidines
/
Virus Diseases
/
Propofol
/
Chronic Disease
/
Anesthetics, Intravenous
/
Hepatitis B, Chronic
/
Electroencephalography
/
Anesthesia
/
Liver Diseases
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Type:
Article
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