Two Cases of External Ophthalmoplegia after Vincristine Treatment in Childhood
Journal of the Korean Ophthalmological Society
;
: 1176-1179, 2016.
Article
in Korean
| WPRIM
| ID: wpr-174265
ABSTRACT
PURPOSE:
To report 2 cases of extraocular muscle paresis with ptosis after vincristine treatment in childhood with acute leukemia. CASESUMMARY:
A 4-year-old girl with acute lymphoblastic leukemia experienced diplopia, esotropia and bilateral ptosis after intravenous vincristine treatment. Ptosis improved after two weeks of pyridoxine treatment with vincristine reduction. After 2 months, left abduction defect and ptosis completely disappeared with pyridoxine treatment. A 23-month-old boy with acute lymphoblastic leukemia had bilateral ptosis with worsening pre-existing infantile esotropia after intravenous vincristine treatment. Bilateral ptosis resolved and esotropia improved after vincristine reduction with pyridoxine treatment for 2 months.CONCLUSIONS:
We observed extraocular muscle paresis and ptosis after vincristine treatment for acute leukemia in pediatric patients. Physicians should be suspicious of toxic neuropathy related to vincristine treatment when patients have extraocular ophthalmoplegia, and physicians should know that vincristine reduction with pyridoxine supplement may be helpful.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paresis
/
Pyridoxine
/
Vincristine
/
Leukemia
/
Ophthalmoplegia
/
Esotropia
/
Diplopia
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2016
Type:
Article
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